Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

doi:10.1016/j.schres.2017.03.017

Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members

The Louis & Gabi Weisfeld School of Social Work

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Abstract

International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Schizophrenia Research
Volume	190
DOIs	https://doi.org/10.1016/j.schres.2017.03.017
State	Published - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 The Authors

Funding

Jonathan Rabinowitz has received research grant(s) support and/or travel support and/or speaker fees and/or consultant fees from Janssen (J&J), Eli Lilly, Pfizer, BiolineRx, Roche, Abraham Pharmaceuticals, Pierre Fabre, Intra-cellular Therapies, Minerva and Amgen. Michael Davidson has received research grant(s) support and/or travel support and/or speaker fees and/or consultant fees from Eli Lilly, Servier, and Minerva and holds stocks in Minerva and Tangent Research. Mark Opler is an employee of ProPhase LLC, receives royalties from MHS Inc. on the sale of the PANSS Manual and has grant funding from Stanley Foundation, QNRF, and NIH. The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008 of which resources are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013). Funding source was not involved in the collection, analysis, and interpretation of data; in the writing of the report; and nor in the decision to submit the paper for publication.

Funders	Funder number
Abraham Pharmaceuticals
BiolineRx
FP7/2007
MHS Inc.
National Institutes of Health
National Institute on Aging	K25AG051782
Eli Lilly and Company
Pfizer
Roche
Qatar National Research Fund
Stanley Foundation
Les Laboratories Pierre Fabre
Seventh Framework Programme
Servier

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2017.03.017

Cite this

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abstract = "International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40\% of ratings had at least one inconsistency flag raised and 10\% had two. Application of flags to clinical rating can improve reliability and validity of trials.",

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Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Abstract

Bibliographical note

Funding

UN SDGs

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