Consistency checks to improve measurement with the Personal and Social Performance Scale (PSP)

Jonathan Rabinowitz; Mark Opler; Alon A. Rabinowitz; Selam Negash; Ariana Anderson; Dong Jing Fu; David Williamson; Alan Kott; Lori L. Davis; Nina R. Schooler

doi:10.1016/j.schres.2020.11.040

Consistency checks to improve measurement with the Personal and Social Performance Scale (PSP)

Jonathan Rabinowitz, Mark Opler, Alon A. Rabinowitz, Selam Negash, Ariana Anderson, Dong Jing Fu, David Williamson, Alan Kott, Lori L. Davis, Nina R. Schooler

The Louis & Gabi Weisfeld School of Social Work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Personal and Social Performance Scale (PSP). One hundred and forty seven flags were identified, 16 flag errors in deriving the PSP decile (i.e., total) score from the four individual domain scores, 74 flag inconsistencies between domain scores relative to Positive and Negative Symptom Scale (PANSS) item ratings and 57 flag inconsistencies between PSP decile score and PANSS items ratings. The flags were applied to assessments from randomized clinical trial data of antipsychotics in schizophrenia from almost 18,000 ratings. Twenty-two flags were raised in at least 5 of 1000 ratings. Nearly 20% of the PSP ratings had at least one inconsistency flag raised. Application of flags to clinical ratings may improve the reliability of ratings and validity of trials.

Original language	English
Pages (from-to)	529-533
Number of pages	5
Journal	Schizophrenia Research
Volume	228
DOIs	https://doi.org/10.1016/j.schres.2020.11.040
State	Published - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 The Authors

Funding

The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking under grant agreement n° 115008 of which resources are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contribution and financial contribution from the European Union Seventh Framework Programme ( FP7/2007-2013 ) and the Elie Wiesel Chair at Bar-Ilan University . Funding sources were not involved in the collection, analysis, and interpretation of data; in the writing of the report; and nor in the decision to submit the paper for publication. The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking under grant agreement n? 115008 of which resources are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contribution and financial contribution from the European Union Seventh Framework Programme (FP7/2007-2013) and the Elie Wiesel Chair at Bar-Ilan University. Funding sources were not involved in the collection, analysis, and interpretation of data; in the writing of the report; and nor in the decision to submit the paper for publication.Jonathan Rabinowitz has received research grant(s) support and/or travel support and/or speaker fees and/or consultant fees from Janssen Research and Development (J&J), Eli Lilly and Company, Pfizer, Lundbeck, Roche, Abraham Pharmaceuticals, Pierre Fabre, Intra-cellular Therapies, Minerva Foundation, Takeda and Amgen.Mark Opler is an employee and shareholder of WCG MedAvante-ProPhase Inc. and has received grant funding from Stanley Foundation, QNRF, and NIH.Ariana Anderson has received grants or contracts from Janssen Research and Development and BlackThorn Therapeutics.Lori L. Davis reports consulting income from Lundbeck, Otsuka, Janssen and research support from Alkermes, Aptinyx, Tonix.Nina R. Schooler has received honoraria and travel support for attendance at advisory board meetings or consultation from Alkermes, GW Pharmaceuticals, Intracellular Therapies, Lundbeck and Otsuka. She has received grant support from Otskua.

Funders	Funder number
Abraham Pharmaceuticals
WCG MedAvante-ProPhase Inc.
Eli Lilly and Company
Pfizer
Roche
Takeda Pharmaceutical Company
Qatar National Research Fund
Seventh Framework Programme
Stanley Foundation
Les Laboratories Pierre Fabre
Minerva Foundation
Seventh Framework Programme
H. Lundbeck A/S

Keywords

Measurement
PANSS
PSP
Personal and Social Performance Scale
Reliability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2020.11.040

Cite this

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title = "Consistency checks to improve measurement with the Personal and Social Performance Scale (PSP)",

abstract = "International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Personal and Social Performance Scale (PSP). One hundred and forty seven flags were identified, 16 flag errors in deriving the PSP decile (i.e., total) score from the four individual domain scores, 74 flag inconsistencies between domain scores relative to Positive and Negative Symptom Scale (PANSS) item ratings and 57 flag inconsistencies between PSP decile score and PANSS items ratings. The flags were applied to assessments from randomized clinical trial data of antipsychotics in schizophrenia from almost 18,000 ratings. Twenty-two flags were raised in at least 5 of 1000 ratings. Nearly 20% of the PSP ratings had at least one inconsistency flag raised. Application of flags to clinical ratings may improve the reliability of ratings and validity of trials.",

keywords = "Measurement, PANSS, PSP, Personal and Social Performance Scale, Reliability",

author = "Jonathan Rabinowitz and Mark Opler and Rabinowitz, {Alon A.} and Selam Negash and Ariana Anderson and Fu, {Dong Jing} and David Williamson and Alan Kott and Davis, {Lori L.} and Schooler, {Nina R.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

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doi = "10.1016/j.schres.2020.11.040",

language = "אנגלית",

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AU - Opler, Mark

AU - Rabinowitz, Alon A.

AU - Negash, Selam

AU - Anderson, Ariana

AU - Fu, Dong Jing

AU - Williamson, David

AU - Kott, Alan

AU - Davis, Lori L.

AU - Schooler, Nina R.

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AB - International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Personal and Social Performance Scale (PSP). One hundred and forty seven flags were identified, 16 flag errors in deriving the PSP decile (i.e., total) score from the four individual domain scores, 74 flag inconsistencies between domain scores relative to Positive and Negative Symptom Scale (PANSS) item ratings and 57 flag inconsistencies between PSP decile score and PANSS items ratings. The flags were applied to assessments from randomized clinical trial data of antipsychotics in schizophrenia from almost 18,000 ratings. Twenty-two flags were raised in at least 5 of 1000 ratings. Nearly 20% of the PSP ratings had at least one inconsistency flag raised. Application of flags to clinical ratings may improve the reliability of ratings and validity of trials.

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Consistency checks to improve measurement with the Personal and Social Performance Scale (PSP)

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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Cite this