Abstract
International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Montgomery-Asberg Depression Rating Scale (MADRS). Twenty-two flags were identified. Seven flags are believed to be strong flags that suggest that a thorough review of rating is warranted. The flags were applied to assessments derived from the NEWMEDS data repository. Almost 65% of ratings had at least one inconsistency flag raised and 22% had two or more. Application of flags to clinical ratings may improve reliability of ratings and validity of trials.
| Original language | English |
|---|---|
| Pages (from-to) | 143-147 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 256 |
| DOIs | |
| State | Published - 1 Sep 2019 |
Bibliographical note
Funding Information:The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking under grant agreement n° 115008 of which resources are composed of European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contribution and financial contribution from the European Union's Seventh Framework Programme ( FP7/2007 – 2013 ). Funding source was not involved in the collection, analysis, and interpretation of data; in the writing of the report; and nor in the decision to submit the paper for publication.
Publisher Copyright:
© 2019
