Congenital hypoaldosteronism: Thirteen year follow-up in identical twins

D. Katznelson, J. Sack, Z. Kraiem, B. Lunenfeld

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Identical male twins suffering from congenital hypoaldosteronism due to a rare adrenal enzyme deficiency between corticostcrone and aldosterone were followed-up from birth till their present age of 13 years. The symptoms of salt loss disappeared and normal growth rate resumed following treatment with DOCA and salt supplementation. Discontinuation of mineralocorticoid administration at the age of 7 years resulted during a 5-year period in a marked decline in their growth rate. Laboratory data revealed a persistent, albeit less pronounced, metabolic impairment. Mineralocorticoid administration was resumed and the twins entered normal puberty and increased their growth rate, emphasizing their need for continued mineralocorticoid administration to maintain adequate growth rate and development.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalHormone Research in Paediatrics
Issue number1
StatePublished - 1979
Externally publishedYes


  • 18-Oxidation defect
  • Adrenal
  • Hypoaldosteronism


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