Confluent and nonconfluent phases in a model of cell tissue

Eial Teomy, David A. Kessler, Herbert Levine

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The Voronoi-based cellular model is highly successful in describing the motion of two-dimensional confluent cell tissues. In the homogeneous version of this model, the energy of each cell is determined solely by its geometric shape and size, and the interaction between adjacent cells is a by-product of this additive energy. We generalize this model so as to allow zero or partial contact between cells. We identify several phases, two of which (solid confluent and liquid confluent) were found in previous studies that imposed confluency as well as others that were not. Transitions in this model may be relevant for understanding both normal development as well as cancer metastasis.

Original languageEnglish
Article number042418
JournalPhysical Review E
Volume98
Issue number4
DOIs
StatePublished - 31 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 American Physical Society.

Funding

E.T. and D.A.K. acknowledge the support of the United States–Israel Binational Science Foundation, Grant No. 2015619. H.L. acknowledges the support of the NSF Grant No. PHY-1605817.

FundersFunder number
National Science FoundationPHY-1605817
United States-Israel Binational Science Foundation2015619

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