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Conducting a microbiome study

  • Julia K. Goodrich
  • , Sara C. Di Rienzi
  • , Angela C. Poole
  • , Omry Koren
  • , William A. Walters
  • , J. Gregory Caporaso
  • , Rob Knight
  • , Ruth E. Ley
  • Cornell University
  • University of Colorado Anschutz Medical Campus
  • Northern Arizona University
  • Argonne National Laboratory
  • University of Colorado Boulder

Research output: Contribution to journalReview articlepeer-review

581 Scopus citations

Abstract

Human microbiome research is an actively developing area of inquiry, with ramifications for our lifestyles, our interactions with microbes, and how we treat disease. Advances depend on carefully executed, controlled, and reproducible studies. Here, we provide a Primer for researchers from diverse disciplines interested in conducting microbiome research. We discuss factors to be considered in the design, execution, and data analysis of microbiome studies. These recommendations should help researchers to enter and contribute to this rapidly developing field.

Original languageEnglish
Pages (from-to)250-262
Number of pages13
JournalCell
Volume158
Issue number2
DOIs
StatePublished - 17 Jul 2014
Externally publishedYes

Funding

FundersFunder number
National Human Genome Research InstituteR01HG004872
National Institute of General Medical SciencesT32GM008759
National Institute of Diabetes and Digestive and Kidney DiseasesP01DK078669
National Institute on Minority Health and Health DisparitiesR01MD011389

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

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