TY - JOUR
T1 - Concentration-dependent viscosity of binary and ternary mixtures of nonassociating proteins
T2 - Measurement and analysis
AU - Grupi, Asaf
AU - Minton, Allen P.
PY - 2013/11/7
Y1 - 2013/11/7
N2 - Using a recently developed automated viscometer (Grupi, A.; Minton, A. P. Anal. Chem. 2012, 84, 10732-10736), the dependence of solution viscosity upon the concentrations of bovine serum albumin, hen egg ovomucoid, and human fibrinogen have been measured individually and in binary and ternary mixtures over a wide range of compositions and at total concentrations of up to 300 g/L. The concentration dependence of viscosity of all solutions is quantitatively described over the entire range of concentrations and compositions by a semiempirical equation requiring specification of only two composition- independent global parameters per protein.
AB - Using a recently developed automated viscometer (Grupi, A.; Minton, A. P. Anal. Chem. 2012, 84, 10732-10736), the dependence of solution viscosity upon the concentrations of bovine serum albumin, hen egg ovomucoid, and human fibrinogen have been measured individually and in binary and ternary mixtures over a wide range of compositions and at total concentrations of up to 300 g/L. The concentration dependence of viscosity of all solutions is quantitatively described over the entire range of concentrations and compositions by a semiempirical equation requiring specification of only two composition- independent global parameters per protein.
UR - http://www.scopus.com/inward/record.url?scp=84887740802&partnerID=8YFLogxK
U2 - 10.1021/jp406530r
DO - 10.1021/jp406530r
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C2 - 24131130
AN - SCOPUS:84887740802
SN - 1520-6106
VL - 117
SP - 13861
EP - 13865
JO - Journal of Physical Chemistry B
JF - Journal of Physical Chemistry B
IS - 44
ER -