Computer assisted antibody re-epitoping

Yanay Ofran (Inventor), Guy Nimrod (Inventor), Sharon Fischman (Inventor), Asael Herman (Inventor)

Research output: Patent


The present invention is directed to a method for generating a library of antigen binding molecules for screening for binding to an epitope of interest, said method comprising: a. selecting a template antigen-binding molecule from a set of possible template antigen binding molecules wherein said selected template does not specifically bind the epitope of interest but is known to specifically bind another epitope; b. selecting at least one residue position in said template antigen-binding molecule for mutation; and c. selecting at least one variant residue to substitute at the at least one residue position selected in b; such that a library containing a plurality of variants of said template is generated.
Original languageEnglish
Patent numberUS11468969B2
StatePublished - 1 Oct 2022

Bibliographical note

US Patent 11,468,969


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