Computed tomography screening for lung cancer: Applicability of an international Protocol in a single-Institution environment

Dorith Shaham, Raphael Breuer, Laurian Copel, Ronit Agid, Arnon Makori, David Kisselgoff, Orly Goitein, Uzi Izhar, Neville Berkman, Norman Heching, Jacob Sosna, Jacob Bar-Ziv, Eugene Libson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Backgorund: The purpose of this study was to assess the applicability of an annual low-dose computed tomography (CT) screening program for lung cancer in a single institution in Israel, which has a relatively lower prevalence of lung cancer compared with other Western countries, and to examine stage distribution of detected lung cancers. Patients and methods: A cohort of 842 former and current smokers underwent baseline low-dose CT screening and a total of 942 annual repeat screenings over a period of 68 months. The definition of positive results on baseline and repeat screening and their diagnostic workup were guided by the common International Early Lung Cancer Action Program protocol. Recommendations for biopsy of suspicious nodules were based on nodule size, nodule growth, nonresolution following antibiotic therapy, and positron emission tomography scan. Results: The test result was positive in 102 of the 842 baseline screenings (12%) and in 45 of the 942 annual repeat screenings (5%), and biopsy was recommended in 12 baseline and 2 annual screenings. Twelve of the 14 cancers diagnosed (86%) were stage I tumors. Conclusion: Our study indicates that the adoption of a common international protocol is feasible, even in a very different clinical setting, yielding a high proportion of early-stage lung cancers.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalClinical Lung Cancer
Issue number4
StatePublished - Jan 2006
Externally publishedYes


The study was supported by grants from the Israel Cancer Society and the Israel Lung Association, Tel Aviv. We thank our study coordinator Hagit Sapir and the I-ELCAP coordinating center and its data analyst Rowena Yip for their invaluable contributions. We also thank the Jacob and Malka Goldfarb Charitable Foundation for its contribution.

FundersFunder number
Israel Cancer Society
Israel Lung Association, Tel Aviv


    • Positron emission tomography
    • Smoking
    • Symptom-prompted malignancies


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