Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect. Computational methods can be utilized as a means to guide the search for biologically relevant antibodies, focusing on specificity and affinity determinants to target a particular region of the antigen. Such an approach would allow for the design of epitope-specific antibodies that will have the desired effect on the function of the targeted protein.
|Number of pages||7|
|Journal||Current Opinion in Structural Biology|
|State||Published - Aug 2018|
Bibliographical noteFunding Information:
This work was supported in part by a Grant from the GIF , the German-Israeli Foundation for Scientific Research and Development.
© 2018 Elsevier Ltd