Computational design of antibodies

Sharon Fischman, Yanay Ofran

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Antibody design aims to create new antibodies with biological activity that can be used in therapy and research. Traditional methods for antibody discovery, such as animal immunization and large-scale library screening, generate antibodies that bind to the target of interest, but do not necessarily have the desired functional effect. Computational methods can be utilized as a means to guide the search for biologically relevant antibodies, focusing on specificity and affinity determinants to target a particular region of the antigen. Such an approach would allow for the design of epitope-specific antibodies that will have the desired effect on the function of the targeted protein.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalCurrent Opinion in Structural Biology
StatePublished - Aug 2018

Bibliographical note

Funding Information:
This work was supported in part by a Grant from the GIF , the German-Israeli Foundation for Scientific Research and Development.

Publisher Copyright:
© 2018 Elsevier Ltd


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