Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

Rachael J. Bloom, Anna K. Kähler, Ann L. Collins, Guanhua Chen, Tyrone D. Cannon, Christina Hultman, Patrick F. Sullivan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.

Original languageEnglish
Pages (from-to)289-290
Number of pages2
JournalSchizophrenia Research
Volume146
Issue number1-3
DOIs
StatePublished - May 2013
Externally publishedYes

Bibliographical note

Funding Information:
Funding for this project was from a NARSAD Distinguished Investigator award (Sullivan) the NIMH (MH052857, Cannon). The funders had no role in the design, execution, analysis, and manuscript preparation.

Keywords

  • Bipolar disorder
  • Copy number variation
  • Discordant
  • Genetics
  • Monozygotic twin
  • Schizophrenia
  • Structural variation

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