Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

Rachael J. Bloom; Anna K. Kähler; Ann L. Collins; Guanhua Chen; Tyrone D. Cannon; Christina Hultman; Patrick F. Sullivan

doi:10.1016/j.schres.2013.02.021

Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

Rachael J. Bloom, Anna K. Kähler, Ann L. Collins, Guanhua Chen, Tyrone D. Cannon, Christina Hultman, Patrick F. Sullivan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.

Original language	English
Pages (from-to)	289-290
Number of pages	2
Journal	Schizophrenia Research
Volume	146
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2013.02.021
State	Published - May 2013
Externally published	Yes

Bibliographical note

Funding Information:
Funding for this project was from a NARSAD Distinguished Investigator award (Sullivan) the NIMH (MH052857, Cannon). The funders had no role in the design, execution, analysis, and manuscript preparation.

Funding

Funding for this project was from a NARSAD Distinguished Investigator award (Sullivan) the NIMH (MH052857, Cannon). The funders had no role in the design, execution, analysis, and manuscript preparation.

Funders	Funder number
National Institute of Mental Health	R01MH052857
National Alliance for Research on Schizophrenia and Depression

Keywords

Bipolar disorder
Copy number variation
Discordant
Genetics
Monozygotic twin
Schizophrenia
Structural variation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2013.02.021

Cite this

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abstract = "Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.",

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AU - Cannon, Tyrone D.

AU - Hultman, Christina

AU - Sullivan, Patrick F.

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Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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