COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR RNA EDITING

Erez Levanon; Shay Ben-Aroya

COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR RNA EDITING

Erez Levanon (Inventor)
, Shay Ben-Aroya (Inventor)

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Patent

Abstract

Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.

Original language	English
Patent number	US2023242906
IPC	C12Q 1/ 6897 A I
Priority date	29/06/21
State	Published - 3 Aug 2023

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title = "COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR RNA EDITING",

abstract = "Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60\% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.",

author = "Erez Levanon and Shay Ben-Aroya",

year = "2023",

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N2 - Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.

AB - Compositions and methods for identifying antisense guide RNA for RNA editing are provided. Accordingly, there is provided a polynucleotide comprising: (i) a nucleic acid sequence encoding a reporter polypeptide comprising a heterologous nucleic acid sequence introducing an in-frame premature stop codon comprising an adenosine preventing translation of a functional reporter polypeptide; and (ii) an additional nucleic acid sequence heterologous to said reporter polypeptide having at least 60% complementarity to said nucleic acid sequence comprising said in-frame premature stop codon.

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M1 - US2023242906

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COMPOSITION AND METHODS FOR IDENTIFYING ANTISENSE GUIDE RNA FOR RNA EDITING

Abstract

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