Comparative Review of the Conserved UL24 Protein Family in Herpesviruses

Odelia Orbaum-Harel, Ronit Sarid

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host–virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.

Original languageEnglish
Article number11268
JournalInternational Journal of Molecular Sciences
Volume25
Issue number20
DOIs
StatePublished - 19 Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Keywords

  • ORF35
  • UL24
  • UL76
  • herpesvirus
  • open reading frame 20 (ORF20)

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