TY - JOUR
T1 - Comparative pharmacological evaluation of Ocimum sanctum and imipramine for antidepressant activity
AU - Moinuddin, Ghulam
AU - Devi, Kshama
AU - Satish, Hanumantharayashetty
AU - Khajuria, Deepak Kumar
PY - 2011
Y1 - 2011
N2 - The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single administration of OS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However there was no significant potentiation of PST. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression.
AB - The present study was undertaken to evaluate the comparative antidepressant activity of Ocimum sanctum (OS) and imipramine using animal models of depression. Imipramine (15 mg/kg/i.p) and herbal extract of OS (500 mg/kg/p.o) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single administration of OS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However there was no significant potentiation of PST. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression.
KW - Antidepressant activity
KW - Imipramine
KW - Ocimum sanctum
UR - http://www.scopus.com/inward/record.url?scp=79955099299&partnerID=8YFLogxK
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AN - SCOPUS:79955099299
SN - 0326-2383
VL - 30
SP - 435
EP - 439
JO - Latin American Journal of Pharmacy
JF - Latin American Journal of Pharmacy
IS - 3
ER -