Comparative pharmacological evaluation of Hypericum perforatum and Rosmarinus officinalis for anti-depressant activity

Ghulam Moinuddin, Kshama Devi, Hanumantharayashetty Satish, Deepak K. Khajuria

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The comparative antidepressant activity of the extracts of Hypericum perforatum and Rosmarinus officinalis using animal models of depression were evaluated. The herbal extracts of Hypericum perforatum (20 mg/kg/p.o.), Rosmarinus officinalis (500 mg/kg/p.o.) were subjected for its antidepressant activity using four different animal models of depression, viz: Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST) in male Wistar rats. The study after single oral administration of Hypericum perforatum and Rosmarinus officinalis extracts revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to control respectively. However, there was no significant potentiation of PST. The results of our study demonstrate the extracts of Hypericum perforatum and Rosmarinus officinalis proved to have a promising antidepressant potential.

Original languageEnglish
Pages (from-to)1028-1032
Number of pages5
JournalLatin American Journal of Pharmacy
Volume30
Issue number5
StatePublished - 2011
Externally publishedYes

Keywords

  • Antidepressant activity
  • Hypericum perforatum
  • Rosmarinus officinalis

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