Combretastatin A-4 analogs as anticancer agents

Anurag Chaudhary; S. N. Pandeya; P. Kumar; P. P. Sharma; S. Gupta; N. Soni; K. K. Verma; G. Bhardwaj

doi:10.2174/138955707782795647

Combretastatin A-4 analogs as anticancer agents

Anurag Chaudhary
, S. N. Pandeya
, P. Kumar
, P. P. Sharma
, S. Gupta
, N. Soni
, K. K. Verma
, G. Bhardwaj

Dr. K.N. Modi Institute of Pharmaceutical Education and Research
Jamia Hamdard University

Research output: Contribution to journal › Review article › peer-review

161 Scopus citations

Abstract

Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

Original language	English
Pages (from-to)	1186-1205
Number of pages	20
Journal	Mini-Reviews in Medicinal Chemistry
Volume	7
Issue number	12
DOIs	https://doi.org/10.2174/138955707782795647
State	Published - Dec 2007
Externally published	Yes

Keywords

Antitubulin
Antivascular
Combretastatin A-4
Cytotoxicity
Structure-activity relationship

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10.2174/138955707782795647

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title = "Combretastatin A-4 analogs as anticancer agents",

abstract = "Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.",

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author = "Anurag Chaudhary and Pandeya, \{S. N.\} and P. Kumar and Sharma, \{P. P.\} and S. Gupta and N. Soni and Verma, \{K. K.\} and G. Bhardwaj",

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AU - Chaudhary, Anurag

AU - Pandeya, S. N.

AU - Kumar, P.

AU - Sharma, P. P.

AU - Gupta, S.

AU - Soni, N.

AU - Verma, K. K.

AU - Bhardwaj, G.

PY - 2007/12

Y1 - 2007/12

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AB - Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.

KW - Antitubulin

KW - Antivascular

KW - Combretastatin A-4

KW - Cytotoxicity

KW - Structure-activity relationship

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IS - 12

ER -

Combretastatin A-4 analogs as anticancer agents

Abstract

Keywords

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