TY - JOUR
T1 - Combating Cystic Fibrosis
T2 - In Search for CF Transmembrane Conductance Regulator (CFTR) Modulators
AU - Noy, Efrat
AU - Senderowitz, Hanoch
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/2/7
Y1 - 2011/2/7
N2 - Open sesame! Compounds that correct the folding, trafficking and gating defects in cystic fibrosis transmembrane conductance regulator (CFTR), the main protein implicated in cystic fibrosis (CF), are of great interest as potential therapeutic agents for this lethal disease. The development of CFTR modulators, highlighting the main challenges in the field and advocating the application of rational rather than brute-force methods, is the focus of this Minireview.
AB - Open sesame! Compounds that correct the folding, trafficking and gating defects in cystic fibrosis transmembrane conductance regulator (CFTR), the main protein implicated in cystic fibrosis (CF), are of great interest as potential therapeutic agents for this lethal disease. The development of CFTR modulators, highlighting the main challenges in the field and advocating the application of rational rather than brute-force methods, is the focus of this Minireview.
KW - Computer-aided drug design
KW - Cystic fibrosis
KW - Cystic fibrosis transmembrane conductance regulator (CFTR)
KW - Modulators
KW - Rational drug design
UR - http://www.scopus.com/inward/record.url?scp=79251546751&partnerID=8YFLogxK
U2 - 10.1002/cmdc.201000488
DO - 10.1002/cmdc.201000488
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C2 - 21275046
SN - 1860-7179
VL - 6
SP - 243
EP - 251
JO - ChemMedChem
JF - ChemMedChem
IS - 2
ER -