TY - JOUR
T1 - Colonization of the thymus by T cell progenitors
T2 - Models for cell-cell interactions
AU - Mehr, Ramit
AU - Segel, Lee
AU - Sharp, Ayala
AU - Globerson, Amiela
PY - 1994/10/7
Y1 - 1994/10/7
N2 - The early events of T-cell generation, i.e. seeding of bone marrow-derived progenitor cells onto the thymic stroma, involve a small fraction up to 1% of thymus cells and are not presently observable. However, these events are crucial in determining the outcome of thymic colonization. In previous-studies we utilized an experimental in vitro model of thymic reconstitution by bone marrow cells to compare normal thymocyte development with the development in conditions of T-cell deficiency, and, in particular, in aging. These studies showed that progenitor cells from old donor bone marrow are deficient in their ability to colonize the thymus, in spite of their ability to divide earlier upon seeding. In this study we apply mathematical and computer modelling in order to analyse early T-cell development and the causes for the developmental disadvantage of old donor bone marrow cells. The results indicate that the competition for seeding niches in the thymic stroma determines the outcome of colonization.
AB - The early events of T-cell generation, i.e. seeding of bone marrow-derived progenitor cells onto the thymic stroma, involve a small fraction up to 1% of thymus cells and are not presently observable. However, these events are crucial in determining the outcome of thymic colonization. In previous-studies we utilized an experimental in vitro model of thymic reconstitution by bone marrow cells to compare normal thymocyte development with the development in conditions of T-cell deficiency, and, in particular, in aging. These studies showed that progenitor cells from old donor bone marrow are deficient in their ability to colonize the thymus, in spite of their ability to divide earlier upon seeding. In this study we apply mathematical and computer modelling in order to analyse early T-cell development and the causes for the developmental disadvantage of old donor bone marrow cells. The results indicate that the competition for seeding niches in the thymic stroma determines the outcome of colonization.
UR - http://www.scopus.com/inward/record.url?scp=0027998139&partnerID=8YFLogxK
U2 - 10.1006/jtbi.1994.1185
DO - 10.1006/jtbi.1994.1185
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AN - SCOPUS:0027998139
SN - 0022-5193
VL - 170
SP - 247
EP - 257
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 3
ER -