Cognitive dysfunction in autoimmune rheumatic diseases

Csaba Oláh, Noa Schwartz, Christopher Denton, Zsófia Kardos, Chaim Putterman, Zoltán Szekanecz

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.

Original languageEnglish
Article number78
JournalArthritis Research and Therapy
Issue number1
StatePublished - 15 Apr 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).


  • Cognitive dysfunction
  • Cognitive function
  • Neuropsychiatric lupus
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Systemic sclerosis


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