Clonal fitness inferred from time-series modelling of single-cell cancer genomes

Keyphrases

• Cancer Genome 100%
• Copy number Variation 100%
• Time Series Modeling 100%
• Fitness Landscape 60%
• Breast Cancer Patients 60%
• Patient-derived Xenograft 60%
• Triple-negative Breast Cancer 60%
• TP53 mutation 40%
• Drug Treatment 20%
• In Cancer 20%
• Tumor 20%
• Population Genetics 20%
• Tumor Protein p53 (TP53) 20%
• Genotype 20%
• Treatment Costs 20%
• Chemotherapy Resistance 20%
• Competitive Dynamics 20%
• Selection Pressure 20%
• Breast Epithelium 20%
• Treatment Resistance 20%
• Cisplatin-based Chemotherapy 20%
• Clonal Competition 20%
• Fitness Cost 20%
• Phylogenetic Lineages 20%
• Cisplatin Resistance 20%
• Drug Selection 20%
• Pressure Dynamics 20%
• Single Cell Sampling 20%
• Fitness Dynamics 20%
• Treatment-naïve 20%
• Resistant Clones 20%
• Lack of Time 20%
• Single-cell Whole-genome Sequencing 20%

Immunology and Microbiology

• Xenograft 100%
• Dynamics 100%
• Cancer Cell 100%
• Lineages 33%
• Phylogeny 33%
• Breast Epithelium 33%
• Whole Genome Sequencing 33%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Dynamics 100%
• Cisplatin 66%
• Population Genetics 33%
• Phylogeny 33%
• Whole Genome Sequencing 33%