Clinical results of gonadotropins

P. Donini, B. Lunenfeld

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Only human gonadotropins of either pituitary or urinary origin are really effective in the treatment of male and female infertility. A method of extracting and purifying these hormones from urine was found, and it was observed that the follicle stimulating hormone:luteinising hormone (FSH:LH) ratio existing in the purified fraction was of the utmost importance in obtaining satisfactory results. This paper suggests the possibility of preparing gonadotropic medication mimicking the FSH:LH ratios found in the normal menstrual cycle, in order to reduce the side effects of the treatment. It deals with the importance of a correct diagnosis and classification of amenorrheic patients when treating female infertility, followed by an examination of the different dosage schemes tried out by various investigators and the necessity of careful treatment monitoring. Finally the paper presents a brief review of the major difficulties encountered in the treatment of male infertility and the cases in which treatment can be effective.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalActa Europaea Fertilitatis
Issue number4
StatePublished - 1974
Externally publishedYes


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