“Cleavable Trifunctional” Approach to Receptor Affinity Labeling: Chemical Regeneration of Binding to A₁-Adenosine Receptors

Medicine & Life Sciences

• 1,3-dipropyl-8-(isothiocyanatophenyl(aminothiocarbonyl-(2-aminoethylaminocarbonyl-(4-methyloxy(phenyl)))))xanthine 35%
• 1,3-dipropylxanthine 27%
• 8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine 31%
• Adenosine A1 Receptors 93%
• Affinity Labels 24%
• Brain 6%
• Cattle 11%
• Disulfides 29%
• Dithiothreitol 34%
• Esters 28%
• Hydroxylamine 100%
• Inhibitory Concentration 50 12%
• isothiocyanic acid 52%
• Ligands 19%
• Membranes 8%
• Proteins 5%
• Purinergic P1 Receptors 17%
• Regeneration 58%
• Sulfhydryl Compounds 15%
• Xanthine 35%
• Xanthines 22%

Engineering & Materials Science

• Affinity Labels 79%
• Brain 28%
• Chemical modification 51%
• Derivatives 28%
• Esters 75%
• Labeling 67%
• Ligands 92%
• Membranes 29%
• Proteins 31%
• Reagents 83%
• Washing 40%

Chemical Compounds

• Affinity Label 19%
• Agonist 13%
• Antagonist 12%
• Cleavage 19%
• Disulfide 22%
• Ester 16%
• Hydroxylamine 74%
• Isothiocyanate 30%
• Ligand 12%
• Modification 7%
• Protein 5%
• Radioligand 31%
• Thiol 11%
• Xanthine 46%