Abstract
Cisplatin was studied for its effect on the copper-catalyzed oxidation of amyloid β (Aβ) peptide. The interaction of cisplatin with Aβ1-16 in the presence of CuII was investigated using cyclic voltammetry and mass spectrometry. The positive shift in the E1/2 value of Aβ1-16-CuII suggests that the interaction of cisplatin alters the copper-binding properties of Aβ1-16. The mass spectrometry data show complete inhibition of copper-catalyzed decarboxylation/deamination of the Asp1 residue of Aβ1-16, while there is a significant decrease in copper-catalyzed oxidation of Aβ1-16 in the presence of cisplatin. Overall, our results provide a novel mode by which cisplatin inhibits copper-catalyzed oxidation of Aβ. These findings may lead to the design of better platinum complexes to treat oxidative stress in Alzheimer's disease and other related neurological disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 10003-10005 |
| Number of pages | 3 |
| Journal | Inorganic Chemistry |
| Volume | 53 |
| Issue number | 19 |
| DOIs | |
| State | Published - 6 Oct 2014 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2014 American Chemical Society.