Abstract
Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 70-78 |
| Number of pages | 9 |
| Journal | Head and Neck |
| Volume | 40 |
| Issue number | 1 |
| Early online date | 17 Nov 2017 |
| DOIs | |
| State | Published - Jan 2018 |
Bibliographical note
Funding Information:This work was partially supported by the Israel Cancer Research Fund (ICRF), by the Israel Science Foundation (ISF) and by the doctoral scholarship for applicable and scientific engineering research, granted to Tamar Dreifuss by the Ministry of Science and Technology, Israel.
Funding Information:
This work was partially supported by the Israel Cancer Research Fund (ICRF) and by the doctoral scholarship for applicable and scientific engineering research, granted to Tamar Dreifuss by the Ministry of Science and Technology, Israel.
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
Keywords
- CT
- cancer
- cisplatin
- gold nanoparticles
- radiotherapy
