Cisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancer

Erez Shmuel Davidi, Tamar Dreifuss, Menachem Motiei, Eliezer Shai, Dimitri Bragilovski, Leon Lubimov, Marc Jose Jonathan Kindler, Aron Popovtzer, Jeremy Don, Rachela Popovtzer

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Background: The purpose of this study was to develop a nanoplatform, which simultaneously acts as radiosensitizer, drug carrier, and tumor imaging agent for head and neck cancer. Methods: We synthesized 20 nm gold nanoparticles, coated with glucose and cisplatin (CG-GNPs). Their penetration into tumor cells and their cellular toxicity were evaluated in vitro. In vivo experiments were conducted to evaluate their impact on tumor growth and their imaging capabilities. Results: The CG-GNPs showed efficient penetration into tumor cells and similar cellular toxicity as cisplatin alone. Combined with radiation, CG-GNPs led to greater tumor reduction than that of radiation alone and radiation with free cisplatin. The CG-GNPs also demonstrated efficient tumor imaging capabilities. Conclusion: Our CG-GNPs have a great potential to increase antitumor effect, overcome resistance to chemotherapeutics and radiation, and allow imaging-guided therapy.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalHead and Neck
Volume40
Issue number1
Early online date17 Nov 2017
DOIs
StatePublished - Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Funding

This work was partially supported by the Israel Cancer Research Fund (ICRF), by the Israel Science Foundation (ISF) and by the doctoral scholarship for applicable and scientific engineering research, granted to Tamar Dreifuss by the Ministry of Science and Technology, Israel. This work was partially supported by the Israel Cancer Research Fund (ICRF) and by the doctoral scholarship for applicable and scientific engineering research, granted to Tamar Dreifuss by the Ministry of Science and Technology, Israel.

FundersFunder number
Israel Cancer Research Fund
Israel Science Foundation
Ministry of science and technology, Israel

    Keywords

    • CT
    • cancer
    • cisplatin
    • gold nanoparticles
    • radiotherapy

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