Circulatory basophilia in guinea pigs with delayed‐type hypersensitivity: Topical antigenic provocation induces circulatory basophilia

D. Sompolinsky; T. Katzenstein; L. Lundberg

doi:10.1111/j.1398-9995.1992.tb02058.x

Circulatory basophilia in guinea pigs with delayed‐type hypersensitivity: Topical antigenic provocation induces circulatory basophilia

D. Sompolinsky, T. Katzenstein, L. Lundberg

University of Copenhagen

Research output: Contribution to journal › Article › peer-review

Abstract

Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (A1(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high‐asthma trait.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1111/j.1398-9995.1992.tb02058.x
State	Published - Aug 1992
Externally published	Yes

Keywords

antigen‐induced
basophilia
guinea pigs, inbred
hereditary
hypersensitivity, cell‐mediated

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10.1111/j.1398-9995.1992.tb02058.x

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abstract = "Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (A1(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high‐asthma trait.",

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AU - Lundberg, L.

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AB - Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (A1(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high‐asthma trait.

KW - antigen‐induced

KW - basophilia

KW - guinea pigs, inbred

KW - hereditary

KW - hypersensitivity, cell‐mediated

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JF - Allergy: European Journal of Allergy and Clinical Immunology

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Circulatory basophilia in guinea pigs with delayed‐type hypersensitivity: Topical antigenic provocation induces circulatory basophilia

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