Circadian organelles: Rhythms at all scales

Rona Aviram, Yaarit Adamovich, Gad Asher

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Circadian clocks have evolved in most light‐sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to subcellular processes. Circadian rhythms in intracellular organelles are an emerging and exciting research arena. We summa-rize herein the current literature for rhythmicity in major intracellular organelles in mammals. These include changes in the morphology, content, and functions of different intracellular organelles. While these data highlight the presence of rhythmicity in these organelles, a gap remains in our knowledge regarding the underlying molecular mechanisms and their functional significance. Fi-nally, we discuss the importance and challenges faced by spatio‐temporal studies on these organelles and speculate on the presence of oscillators in organelles and their potential mode of commu-nication. As circadian biology has been and continues to be studied throughout temporal and spatial axes, circadian organelles appear to be the next frontier.

Original languageEnglish
Article number2447
Issue number9
StatePublished - 16 Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the author. Li-censee MDPI, Basel, Switzerland.


  • Circadian clocks
  • Endoplasmic reticulum
  • Lysosomes
  • Mitochondria
  • Nucleus
  • Organelles
  • Rhythms


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