Circadian effects of β-endorphin, metatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures

Shlomo Yehuda, David I. Mostofsky

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Circadian effects on PTZ-induced seizure thresholds alone and following drug pretreatment were studied in 720 male rats, divided into 40 groups of 18 each. Each rat was tested only once, at one of eight clock hours and under one of five drug pretreatments. Clear cyclic changes in thresholds were found. Drug effects on the rhythm were similar for DSIP and β-endorphin, which produced higher thresholds during the night periods, while d-amphetamine and melatonin decreased the threshold during that period. All drugs increased the vulnerability to seizures relative to the saline control during the daytime, while only β-endorphin and DSIP offered improved protection during the night hours. The possibility of dopaminergic mediation is suggested to account for the effects.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalPeptides
Volume14
Issue number2
DOIs
StatePublished - 1993

Keywords

  • Circadian rhythm
  • DSIP
  • Melatonin
  • PTZ
  • Seizure threshold
  • d-Amphetamine
  • β-Endorphin

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