Cilengitide induces autophagy-mediated cell death in glioma cells

Stephanie L. Lomonaco; Susan Finniss; Cunli Xiang; Hae Kyung Lee; Wei Jiang; Nancy Lemke; Sandra A. Rempel; Tom Mikkelsen; Chaya Brodie

doi:10.1093/neuonc/nor073

Cilengitide induces autophagy-mediated cell death in glioma cells

Stephanie L. Lomonaco, Susan Finniss, Cunli Xiang, Hae Kyung Lee, Wei Jiang, Nancy Lemke, Sandra A. Rempel, Tom Mikkelsen, Chaya Brodie

The Mina and Everard Goodman Faculty of Life Sciences

Henry Ford Health System

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation.

Original language	English
Pages (from-to)	857-865
Number of pages	9
Journal	Neuro-Oncology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1093/neuonc/nor073
State	Published - Aug 2011

Keywords

Autophagy
Beclin-1
Cilengitide
Glioma cells
Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/neuonc/nor073

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abstract = "We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation.",

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AU - Lomonaco, Stephanie L.

AU - Finniss, Susan

AU - Xiang, Cunli

AU - Lee, Hae Kyung

AU - Jiang, Wei

AU - Lemke, Nancy

AU - Rempel, Sandra A.

AU - Mikkelsen, Tom

AU - Brodie, Chaya

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AB - We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation.

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KW - Cilengitide

KW - Glioma cells

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Cilengitide induces autophagy-mediated cell death in glioma cells

Abstract

Keywords

UN SDGs

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