Chromosomal numerical aberrations in oral lichen planus

N. Yarom, T. Shani, N. Amariglio, S. Taicher, I. Kaplan, M. Vered, G. Rechavi, L. Trakhtenbrot, A. Hirshberg

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The malignant potential of oral lichen planus (OLP) has been a matter of serious controversy. We aimed to detect chromosomal numerical aberrations in cells of brush samples collected from affected mucosa. The samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) with chromosomes 2 and 8 centromeric probes. We analyzed 57 persons with OLP and 33 control individuals. A cut-off value of aneuploid cells was determined as 1.1%. Aneuploid cells were found in 16 persons with OLP (28.1%); in 10 individuals (17.5%), over 5% of the cells were aneuploid. Aneuploid cells were also detected in normal-looking mucosa of seven persons with OLP. One person with OLP developed squamous cell carcinoma; 10% of the cells examined were aneuploid. OLP carries an increased risk for chromosomal instability. Identifying aneuploid cells in a brush sample and the combined morphological and FISH analysis can increase the specificity in predicting the malignant potential of OLP.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalJournal of Dental Research
Issue number5
StatePublished - 1 May 2009
Externally publishedYes


  • Aneuploidy
  • Chromosomal instability
  • Oral cancer
  • Oral lichen planus
  • Ploidy


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