Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

Ygal Rotenstreich; Daniel Ben-Ner; Inbal Sharvit-Ginon; Ramit Ravona-Springer; Michal Beeri; Ifat Sher

doi:10.1117/12.2251428

Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

Ygal Rotenstreich, Daniel Ben-Ner, Inbal Sharvit-Ginon, Ramit Ravona-Springer, Michal Beeri, Ifat Sher

The Leslie and Susan Gonda Multidisciplinary Brain Research Center

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.

Original language	English
Title of host publication	Opthalmic Technologies XXVII
Editors	Per G. Soderberg, Arthur Ho, Fabrice Manns
Publisher	SPIE
ISBN (Electronic)	9781510605312
DOIs	https://doi.org/10.1117/12.2251428
State	Published - 2017
Event	27th Conference on Ophthalmic Technologies - San Francisco, United States Duration: 28 Jan 2017 → 29 Jan 2017

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10045
ISSN (Print)	1605-7422

Conference

Conference	27th Conference on Ophthalmic Technologies
Country/Territory	United States
City	San Francisco
Period	28/01/17 → 29/01/17

Bibliographical note

Publisher Copyright:
© 2017 SPIE.

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10.1117/12.2251428

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Rotenstreich, Y., Ben-Ner, D., Sharvit-Ginon, I., Ravona-Springer, R., Beeri, M., & Sher, I. (2017). Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment. In P. G. Soderberg, A. Ho, & F. Manns (Eds.), Opthalmic Technologies XXVII Article 100451Z (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10045). SPIE. https://doi.org/10.1117/12.2251428

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title = "Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment",

abstract = "The pupil responses of 15 cognitively normal subjects (ages 60-74) were examined in response to 76 focal red and blue light stimuli using a chromatic multifocal pupillometer (CMP). Subjects with low cognitive scores as determined as by Montreal Cognitive Assessment testing, presented significantly weaker and sluggish pupil responses in peripheral and central locations of the visual field in response to red and blue light. Our findings suggests that the CMP may present a novel objective, non-invasive, low cost technique for early diagnosis of cognitive decline that may serve for Alzheimer Disease prevention and as sensitive outcome measure of therapeutic effects.",

author = "Ygal Rotenstreich and Daniel Ben-Ner and Inbal Sharvit-Ginon and Ramit Ravona-Springer and Michal Beeri and Ifat Sher",

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Rotenstreich, Y, Ben-Ner, D, Sharvit-Ginon, I, Ravona-Springer, R, Beeri, M & Sher, I 2017, Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment. in PG Soderberg, A Ho & F Manns (eds), Opthalmic Technologies XXVII., 100451Z, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10045, SPIE, 27th Conference on Ophthalmic Technologies, San Francisco, United States, 28/01/17. https://doi.org/10.1117/12.2251428

Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment. / Rotenstreich, Ygal; Ben-Ner, Daniel; Sharvit-Ginon, Inbal et al.
Opthalmic Technologies XXVII. ed. / Per G. Soderberg; Arthur Ho; Fabrice Manns. SPIE, 2017. 100451Z (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10045).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Chromatic multifocal pupillometer for objective early diagnosis of mild cognitive impairment

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