Chromate allergy in Northern Israel in relation to exposure to cement and detergents

Khalaf Kridin, Reuven Bergman, Mogher Khamaisi, Sara Weltfriend

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background The prevalence of chromate allergy has declined worldwide in the last decades. Objectives The aim of the study was to assess tendencies in chromate allergy in northern Israel and its possible causes. Methods Retrospective analysis of patch test data during 1999-2013 and a review of the medical records of patients with chromate allergy were conducted. Results A total of 4846 consecutive patients were patch tested, of whom 146 (3%) were found to be chromate sensitive. The prevalence of chromate allergy decreased significantly from 4.7% in 1999-2001 to 2.8% in 2002-2004 (P = 0.02). Since then, no significant fluctuations have occurred. A gradual and consistent decline in chromate allergy was recorded among women from 4.8% in 1999-2001 to 2.3% in 2008-2010. Cement (18.4%) was the most frequent source of exposure and was mainly observed in men. The frequency of clinically relevant cement exposure increased significantly from 7.7% in 2002-2004 to 28.7% in 2011-2013 (P = 0.04), whereas the frequency of relevant detergent exposure decreased significantly from 25% in 1999-2001 to 5.7% in 2011-2013 (P = 0.04). Hand (68.5%) was the most frequently involved anatomical site. Conclusions The prevalence of chromate allergy in northern Israel is stable in the general population and gradually decreasing among women. These changes may be caused by reduced exposure to water-soluble hexavalent chromium in detergents but not in cement.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
Issue number3
StatePublished - 1 May 2016
Externally publishedYes

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© 2016 American Contact Dermatitis Society.


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