TY - JOUR
T1 - Choroid plexus cysts and aneuploidy
AU - Peleg, David
AU - Yankowitz, Jerome
PY - 1998/7
Y1 - 1998/7
N2 - The association of choroid plexus cysts with fetal aneuploidy, particularly trisomy 18, was first noted in 1986. Through the years there have been numerous reports on this subject, but no consensus has been reached with regard to chromosomal risk. In this review, we attempt to summarise published reports on second trimester choroid plexus cysts, with an emphasis on the strengths and weaknesses of each report. Based on these reports, additional malformations are a significant risk factor for aneuploidy and an indication for determination of fetal karyotype. The management of isolated choroid plexus cysts remains controversial.
AB - The association of choroid plexus cysts with fetal aneuploidy, particularly trisomy 18, was first noted in 1986. Through the years there have been numerous reports on this subject, but no consensus has been reached with regard to chromosomal risk. In this review, we attempt to summarise published reports on second trimester choroid plexus cysts, with an emphasis on the strengths and weaknesses of each report. Based on these reports, additional malformations are a significant risk factor for aneuploidy and an indication for determination of fetal karyotype. The management of isolated choroid plexus cysts remains controversial.
KW - Aneuploidy
KW - Choroid plexus cyst
KW - Trisomy 18
KW - Trisomy 21
UR - http://www.scopus.com/inward/record.url?scp=0031813241&partnerID=8YFLogxK
U2 - 10.1136/jmg.35.7.554
DO - 10.1136/jmg.35.7.554
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C2 - 9678699
AN - SCOPUS:0031813241
SN - 0022-2593
VL - 35
SP - 554
EP - 557
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
IS - 7
ER -