Chorioamnionitis and its association with neonatal and maternal adverse outcomes in women with and without epidural analgesia administration

Michal Lipschuetz, Joshua Guedalia, Lina Daud - Sabag, Zvi Arye Shimonovitz, Simcha Yagel, Gilad Karavani

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate neonatal fever and adverse maternal and neonatal outcomes in febrile laboring women and assess whether the time interval between epidural analgesia (EA) administration and chorioamnionitis is associated with these complications. Methods: A retrospective cohort study at a university affiliated medical center between 2003 and 2015. Included were women who underwent term vaginal delivery attempt and diagnosed with chorioamnionitis. The primary outcomes compared between febrile women with and without EA were neonatal fever and adverse neonatal and maternal outcomes. The association between time from EA to fever (<6, 6–12, >12 h) and maternal and neonatal complications was also assessed. Results: During the study period, 1,933 women with chorioamnionitis were assessed. Of them, 1,810 (93.6%) received EA prior to fever and 123 (6.4%) febrile parturients did not receive EA. Neonatal fever and other neonatal adverse outcomes were similar in the EA vs. non-EA group (2.2% vs. 0.8% and 2.7% vs. 4.9% (NS)), except for transient tachypnea of the newborn rates which were lower in the EA group (1.4% vs. 4.1%, p = 0.043). Maternal complications were similar, besides for higher rates of instrumental deliveries found in the EA group (24.0% vs. 5.7%, p < 0.001). Time between EA and fever onset was not associated with neonatal complications in logistic regression analysis. Conclusion: Neonatal and maternal outcomes are similar in febrile laboring women with and without EA. The time interval between EA and onset of fever is not associated with increased rates of neonatal fever or adverse outcomes and should not affect the management of labor.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
StatePublished - Jun 2022

Bibliographical note

Funding Information:
The authors thank all the dedicated embryologists of the Fertility and IVF Unit at Soroka University Medical Center.

Publisher Copyright:
© 2022 Elsevier B.V.


  • Chorioamnionitis
  • Epidural analgesia
  • Neonatal fever
  • Sepsis


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