Chirality of proteinoid nanoparticles made of lysine and phenylalanine

Liroy Lugasi, Gil Otis, Matan Oliel, Shlomo Margel, Yitzhak Mastai

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Proteinoid nanoparticles composed of l-lysine and l-phenylalanine were prepared and showed enantioselective adsorption of l-amino acids at various pH values, emphasizing the chiral nature of the particles. The adsorption was examined using circular dichroism, isothermal titration calorimetry and ζ-potential measurements. Positively charged ammonium moieties on the proteinoid surface are most likely responsible for the enantioselective adsorption owing to their chirality which originates from l-lysine. Accordingly, a higher enantiomeric excess was found for amino acids such as alanine with a more negative charge.

Original languageEnglish
Pages (from-to)3788-3796
Number of pages9
JournalPolymers for Advanced Technologies
Issue number11
StatePublished - Nov 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Polymers for Advanced Technologies published by John Wiley & Sons Ltd.


  • chiral adsorption
  • chiral separation
  • chirality
  • polymer nanoparticles
  • proteinoid nanoparticles


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