Herein we report on the synthesis of chiral mesoporous silica (CMS) that can be used for chiral separation from a racemic mixture of two enantiomers. The CMS with a pore size of 3-5 nm and a high surface area of 725 m2 g-1 was synthesized by templating chiral block copolymers (CBCs) of polyethylene oxide (PEG) and D/L-aspartic acid (D/L-AspA), [PEO45-b-(D/L-AspA)10]. The chiral mesopores were characterized by HRTEM, small angle XRD and BET. The chiral resolution abilities and the chiral separation kinetics of the copolymer-extracted CMS were investigated using a racemic mixture of valine by circular dichroism (CD) and optical polarimetry. The chiral resolution of the CMS was further verified with a racemic mixture of alanine. A chiral selectivity factor of 7.52 was found for the specific enantiomer which is adsorbed preferably. These results allow a new approach towards enantiomeric separation and other enantiomeric applications of novel CMS. © 2009 Elsevier Inc. All rights reserved.
|Number of pages||8|
|Journal||Microporous and Mesoporous Materials|
|State||Published - 1 Apr 2010|
Bibliographical noteFunding Information:
We would like to acknowledge the Israel Science Foundation (ISF), the Government of Israel for the financial assistance. We would also like to acknowledge the Department of Chemistry and the Institute of Nanotechnology, Bar-Ilan University, Israel for providing the experimental facilities.
- Chiral block copolymers
- Chiral mesoporous silica
- Chiral separation