Abstract
Newly synthesized polymercaptal microspheres of 0.8 ± 0.02 μm were shown to have a specific and fast intake of mercury compounds over a whole range of pH while maintaining low toxicity. The microspheres bind easily with mercury compounds which are already bound to the biological mercury binders, albumin or cysteine. Mercury was recovered completely from the microspheres by using a solution of thiourea in hydrochloric acid. Due to their high surface area, low toxicity, and strong affinity toward mercury compounds, the microspheres have a potential use as a new oral drug for treatment in cases of mercury poisoning.
| Original language | English |
|---|---|
| Pages (from-to) | 1030-1034 |
| Number of pages | 5 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 71 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1982 |
| Externally published | Yes |
Bibliographical note
Funding Information:The research was supported by the Committee on Prevention and Research in Occupational Health, The Government of Israel.
Funding
The research was supported by the Committee on Prevention and Research in Occupational Health, The Government of Israel.
| Funders |
|---|
| Government of Israel |
Keywords
- Chelation—mercury, polymercaptal microspheres, new potential antidote for mercury poisoning
- Mercury—chelation by polymercaptal microspheres, new potential antidote for poisoning
- Microspheres—chelation of mercury, polymercaptal, new potential antidote for mercury poisoning
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