Characterization of glucose transport system in keratinocytes: Insulin and IGF-1 differentially affect specific transporters

Shlomzion Shen, Efrat Wertheimer, Sanford R. Sampson, Tamar Tennenbaum

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Skin is one of the major tissues displaying chronic diabetic complications. We have studied glucose transport following stimulation with insulin and IGF-1 in cultured mouse keratinocytes. In proliferating cells, acute stimulation with insulin and IGF-1 increased glucose uptake. Insulin translocated glucose transporters 1 and 5, whereas IGF-1 translocated glucose transporters 2 and 3. With differentiation, glucose transporter 3 expression increased and the expression of glucose transporters 1, 2, and 5 decreased. No increase in glucose uptake was observed, however, following stimulation with either hormone. These results indicate that insulin and IGF-1 differentially regulate glucose uptake as well as expression and translocation of specific transporters in skin keratinocytes.

Original languageEnglish
Pages (from-to)949-954
Number of pages6
JournalJournal of Investigative Dermatology
Issue number6
StatePublished - 2000

Bibliographical note

Funding Information:
Supported in part by the Sorrell Foundation and a grant from the Israel Science Foundation funded by the Israel Academy of Sciences. This work was supported by a grant from the Smokeless Tobacco Research Council. EW is a recipient of a Career Development Award from the Juvenile Diabetes Foundation International. SRS is the incumbent of the Louis Fisher Chair in Cellular Pathology.


  • Glucose transport
  • Glucose transporters
  • Growth factors
  • Insulin
  • Keratinocytes
  • Skin


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