Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol - An anticancer drug

Olga Grinberg; Michal Hayun; Benjamin Sredni; Aharon Gedanken

doi:10.1016/j.ultsonch.2006.11.004

Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol - An anticancer drug

Olga Grinberg, Michal Hayun, Benjamin Sredni, Aharon Gedanken

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPC-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells.

Original language	English
Pages (from-to)	661-666
Number of pages	6
Journal	Ultrasonics Sonochemistry
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.ultsonch.2006.11.004
State	Published - Jul 2007

Keywords

Anticancer drug carrier
Bovine serum albumin
Proteinaceous microspheres
Sonochemistry
Taxol

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10.1016/j.ultsonch.2006.11.004

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abstract = "Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPC-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells.",

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AU - Sredni, Benjamin

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Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol - An anticancer drug

Abstract

Keywords

UN SDGs

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