Characteristics of cerebral sinus venous thrombosis in men

Naaem Simaan, Andrei Filioglo, Asaf Honig, Shorooq Aladdin, Jose E. Cohen, Ronen R. Leker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype that is more common in women, yet data regarding sex-specific characteristics are sparse. We aimed to study male-specific characteristics among patients with CSVT. Materials & methods: Data of consecutive patients with CSVT, admitted to a single medical centre between 2005 and 2020, were retrospectively studied. Demographics, clinical presentations, radiological and outcome parameters were compared between male and female patients. Male patients were further divided into older and younger than 35 years old for additional comparisons. Results: Out of 15,224 patients diagnosed with stroke, 150 patients (1%) presented with CSVT and 47 (31.3%) of them were males. Males had significantly higher rates of previous thrombotic events (22% vs. 7%, p =.009), malignancies (32% vs. 16%, p =.022) and Behcet's disease (22% vs. 2%, p <.001). Additionally, we found that malignancies were significantly more prevalent in older males (48% vs. 17%, p =.022), while Behcet's disease was more often found in younger patients (35% vs. 9%, p =.032). Additional age-related differences in disease characteristics among male patients included a higher frequencies of papilledema (42% vs. 13%, p =.028), and cortical vein thromboses (21% vs. 0% p =.021) observed in the younger men. Conclusions: There are important differences in risk factors for thrombosis between men and women with CSVT. Behcet's disease is common in younger men, while malignancies are major causes of CSVT in older men.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalActa Neurologica Scandinavica
Issue number3
StatePublished - Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • Behcet's disease
  • aetiology
  • cerebral sinus venous thrombosis
  • males
  • malignancies


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