Changes in circadian rhythms of thermoregulation and motor activity in rats as a function of aging: Effects of d-amphetamine and α-MSH

Shlomo Yehuda, Ralph L. Carasso

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Thermoregulatory and motor activity circadian cycles are age-dependent. While the level of thermoregulation and motor activity remained almost at the same level during the first 1-15 months during the light portion of the 24-hr cycle, a significant decrease in the level of both rhythms was observed during the dark period. Therefore, older rats exhibited reversed cycles compared with younger rats. Treatments with d-amphetamine resulted in the enhancement of reversal of the cycles. Rats treated with α-MSH failed to exhibit a reversal of the cycles. While the effects of d-amphetamine are mediated by the brain DA mesolimbic pathway, it seems that α-MSH acts on the dopaminergic system at different sites of action.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalPeptides
Volume4
Issue number6
DOIs
StatePublished - 1983

Keywords

  • Aging
  • Circadian rhythms
  • Motor activity
  • Thermoregulation
  • d-Amphetamine
  • α-MSH

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