Centromeres in cell division, evolution, nuclear organization and disease

Amanda Gonçalves Dos Santos Silva, Rahul Sarkar, Jana Harizanova, Amanda Guffei, Michael Mowat, Yuval Garini, Sabine Mai

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.

Original languageEnglish
Pages (from-to)2040-2058
Number of pages19
JournalJournal of Cellular Biochemistry
Volume104
Issue number6
DOIs
StatePublished - 15 Aug 2008

Keywords

  • 3D nucleus
  • Cancer
  • Cell division
  • Centromere
  • Evolution
  • Imaging

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