Central nervous system transplantation benefitted by low-level laser irradiation

Semion Rochkind; Rachel Lubart; Yoram Wollman; Rabbi Simantov; Moshe Nissan; Lilian Barr-Nea

Central nervous system transplantation benefitted by low-level laser irradiation

Semion Rochkind, Rachel Lubart, Yoram Wollman, Rabbi Simantov, Moshe Nissan, Lilian Barr-Nea

Dep of Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

7 Scopus citations

Abstract

Effect of low-level laser irradiation on the central nervous system transplantation is reported. Embryonal brain allografts were transplanted into the brain of 20 adult rats and peripheral nerve graft transplanted into the severely injured spinal cord of 16 dogs. The operated wound of 10 rats and 8 dogs were exposed daily for 21 days to low-power laser irradiation CW HeNe laser (35 mW, 632.8 nm, energy density of 30 J/cm² at each point for rats and 70 J/cm² at each point for dogs). This study shows that (i) the low-level laser irradiation prevents extensive glial scar formation (a limiting factor in CNS regeneration) between embryonal transplants and host brain; (ii) Dogs made paraplegic by spinal cord injury were able to walk 3-6 months later. Recovery of these dogs was effected by the implantation of a fragment of autologous sciatic nerve at the site of injury and subsequently exposing the dogs to low-level laser irradiation. The effect of laser irradiation on the embryonal nerve cells grown in tissue culture was also observed. We found that low-level laser irradiation induced intensive migration of neurites outward of the aggregates. The results of the present study and our previous investigations suggest that low-level laser irradiation is a novel tool for treatment of peripheral and central nervous system injuries.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	Stephen N. Joffe, Kazuhiko Atsumi
Publisher	Publ by Int Soc for Optical Engineering
Pages	301-312
Number of pages	12
ISBN (Print)	0819402419
State	Published - 1990
Externally published	Yes
Event	Proceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II - Los Angeles, CA, USA Duration: 14 Jan 1990 → 19 Jan 1990

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1200
ISSN (Print)	0277-786X

Conference

Conference	Proceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II
City	Los Angeles, CA, USA
Period	14/01/90 → 19/01/90

Cite this

Rochkind, S., Lubart, R., Wollman, Y., Simantov, R., Nissan, M., & Barr-Nea, L. (1990). Central nervous system transplantation benefitted by low-level laser irradiation. In S. N. Joffe, & K. Atsumi (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 301-312). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1200). Publ by Int Soc for Optical Engineering.

Rochkind, Semion ; Lubart, Rachel ; Wollman, Yoram et al. / Central nervous system transplantation benefitted by low-level laser irradiation. Proceedings of SPIE - The International Society for Optical Engineering. editor / Stephen N. Joffe ; Kazuhiko Atsumi. Publ by Int Soc for Optical Engineering, 1990. pp. 301-312 (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Central nervous system transplantation benefitted by low-level laser irradiation",

abstract = "Effect of low-level laser irradiation on the central nervous system transplantation is reported. Embryonal brain allografts were transplanted into the brain of 20 adult rats and peripheral nerve graft transplanted into the severely injured spinal cord of 16 dogs. The operated wound of 10 rats and 8 dogs were exposed daily for 21 days to low-power laser irradiation CW HeNe laser (35 mW, 632.8 nm, energy density of 30 J/cm2 at each point for rats and 70 J/cm2 at each point for dogs). This study shows that (i) the low-level laser irradiation prevents extensive glial scar formation (a limiting factor in CNS regeneration) between embryonal transplants and host brain; (ii) Dogs made paraplegic by spinal cord injury were able to walk 3-6 months later. Recovery of these dogs was effected by the implantation of a fragment of autologous sciatic nerve at the site of injury and subsequently exposing the dogs to low-level laser irradiation. The effect of laser irradiation on the embryonal nerve cells grown in tissue culture was also observed. We found that low-level laser irradiation induced intensive migration of neurites outward of the aggregates. The results of the present study and our previous investigations suggest that low-level laser irradiation is a novel tool for treatment of peripheral and central nervous system injuries.",

author = "Semion Rochkind and Rachel Lubart and Yoram Wollman and Rabbi Simantov and Moshe Nissan and Lilian Barr-Nea",

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Rochkind, S, Lubart, R, Wollman, Y, Simantov, R, Nissan, M & Barr-Nea, L 1990, Central nervous system transplantation benefitted by low-level laser irradiation. in SN Joffe & K Atsumi (eds), Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1200, Publ by Int Soc for Optical Engineering, pp. 301-312, Proceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II, Los Angeles, CA, USA, 14/01/90.

Central nervous system transplantation benefitted by low-level laser irradiation. / Rochkind, Semion; Lubart, Rachel; Wollman, Yoram et al.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / Stephen N. Joffe; Kazuhiko Atsumi. Publ by Int Soc for Optical Engineering, 1990. p. 301-312 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1200).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Effect of low-level laser irradiation on the central nervous system transplantation is reported. Embryonal brain allografts were transplanted into the brain of 20 adult rats and peripheral nerve graft transplanted into the severely injured spinal cord of 16 dogs. The operated wound of 10 rats and 8 dogs were exposed daily for 21 days to low-power laser irradiation CW HeNe laser (35 mW, 632.8 nm, energy density of 30 J/cm2 at each point for rats and 70 J/cm2 at each point for dogs). This study shows that (i) the low-level laser irradiation prevents extensive glial scar formation (a limiting factor in CNS regeneration) between embryonal transplants and host brain; (ii) Dogs made paraplegic by spinal cord injury were able to walk 3-6 months later. Recovery of these dogs was effected by the implantation of a fragment of autologous sciatic nerve at the site of injury and subsequently exposing the dogs to low-level laser irradiation. The effect of laser irradiation on the embryonal nerve cells grown in tissue culture was also observed. We found that low-level laser irradiation induced intensive migration of neurites outward of the aggregates. The results of the present study and our previous investigations suggest that low-level laser irradiation is a novel tool for treatment of peripheral and central nervous system injuries.

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Rochkind S, Lubart R, Wollman Y, Simantov R, Nissan M, Barr-Nea L. Central nervous system transplantation benefitted by low-level laser irradiation. In Joffe SN, Atsumi K, editors, Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering. 1990. p. 301-312. (Proceedings of SPIE - The International Society for Optical Engineering).

Central nervous system transplantation benefitted by low-level laser irradiation

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