TY - JOUR
T1 - Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma
AU - Kaplinsky, C.
AU - Toren, A.
AU - Neumann, Y.
AU - Mandel, M.
AU - Kenet, G.
AU - Sharon, N.
AU - Rechavi, G.
AU - Biniaminov, M.
AU - Rubanov, V.
AU - Rosenthal, E.
AU - Rosner, E.
AU - Mark, Z.
AU - Amariglio, N.
AU - Brok- Simoni, F.
PY - 1997/2
Y1 - 1997/2
N2 - Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato- Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (AICI). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.
AB - Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato- Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (AICI). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.
KW - Ki-1/CD30 positive lymphoma
KW - childhood malignancies
KW - non-Hodgkin's lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0031030169&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-911X(199702)28:2<132::AID-MPO7>3.0.CO;2-L
DO - 10.1002/(SICI)1096-911X(199702)28:2<132::AID-MPO7>3.0.CO;2-L
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C2 - 8986149
AN - SCOPUS:0031030169
SN - 0098-1532
VL - 28
SP - 132
EP - 135
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 2
ER -
