Cellular superresolved imaging of multiple markers using temporally flickering nanoparticles

Tali Ilovitsh, Yossef Danan, Rinat Meir, Amihai Meiri, Zeev Zalevsky

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In this paper we present a technique aimed for simultaneous detection of multiple types of gold nanoparticles (GNPs) within a biological sample, using lock-in detection. We image the sample using a number of modulated laser beams that correspond to the number of GNP species that label a given sample. The final image where the GNPs are spatially separated is obtained computationally. The proposed method enables the simultaneous superresolved imaging of different areas of interest within biological sample and also the spatial separation of GNPs at sub-diffraction distances, making it a useful tool in the study of intracellular trafficking pathways in living cells.

Original languageEnglish
Article number10965
JournalScientific Reports
StatePublished - 28 May 2015


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