TY - JOUR
T1 - CDB - A database for protein heterodimeric complexes
AU - Aker, Malka
AU - Ohanona, Shirly
AU - Fisher, Shira
AU - Katsman, Efrat
AU - Dvorkin, Shirit
AU - Kopelowitz, Efrat
AU - Goldstein, Moshe
AU - Barnett-Itzhaki, Zohar
AU - Amitay, Moshe
N1 - Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press. All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Crystallographic structures of protein complexes are essential to develop proteomic and structural biology methods, as prediction of protein-protein interaction (PPI) sites and protein-protein docking. Such structures can aid the development of protein complexation inhibitors. Complex DataBase (CDB), accessible at www.jct-bioinfo.com/cdb/search, is a database web application for heterodimeric protein crystallographic complexes along with the crystallographic structures of each individual unbound protein. Direct access to crystallographic structures of protein complexes, along with provided annotations, can serve as starting point for constructing new experimental protein complexes sets of any type, for protein binding studies, and the development and evaluation of PPIs prediction methods.
AB - Crystallographic structures of protein complexes are essential to develop proteomic and structural biology methods, as prediction of protein-protein interaction (PPI) sites and protein-protein docking. Such structures can aid the development of protein complexation inhibitors. Complex DataBase (CDB), accessible at www.jct-bioinfo.com/cdb/search, is a database web application for heterodimeric protein crystallographic complexes along with the crystallographic structures of each individual unbound protein. Direct access to crystallographic structures of protein complexes, along with provided annotations, can serve as starting point for constructing new experimental protein complexes sets of any type, for protein binding studies, and the development and evaluation of PPIs prediction methods.
KW - Crystallography
KW - Protein complex interactions
KW - Protein dimers
KW - Protein-protein interface
KW - Structure
UR - http://www.scopus.com/inward/record.url?scp=85065866055&partnerID=8YFLogxK
U2 - 10.1093/protein/gzy030
DO - 10.1093/protein/gzy030
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C2 - 30452718
AN - SCOPUS:85065866055
SN - 1741-0126
VL - 31
SP - 361
EP - 365
JO - Protein Engineering, Design and Selection
JF - Protein Engineering, Design and Selection
IS - 10
ER -