CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

Perri Rozenberg; Hadar Reichman; Israel Zab-Bar; Michal Itan; Metsada Pasmanik-Chor; Carine Bouffi; Udi Qimron; Ido Bachelet; Patricia C. Fulkerson; Marc E. Rothenberg; Ariel Munitz

doi:10.1038/s41598-017-06397-4

CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

Perri Rozenberg, Hadar Reichman, Israel Zab-Bar, Michal Itan, Metsada Pasmanik-Chor, Carine Bouffi, Udi Qimron, Ido Bachelet, Patricia C. Fulkerson, Marc E. Rothenberg, Ariel Munitz

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 ^Tg /Cd300f ^-/- mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 ^Tg /Cd300f ^-/- mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f ^-/- mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 ^Tg /CD300f ^-/- were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.

Original language	English
Article number	5922
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-06397-4
State	Published - 1 Dec 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).

Funding

AM and MER are supported by the US-Israel Bi-national Science Foundation (grant no. 2011244), MER by NIH R37 A1045898;

Funders	Funder number
US-Israel bi-national Science Foundation	2011244
National Institutes of Health	R37 A1045898
National Institute of Allergy and Infectious Diseases	R37AI045898
National Institute of Diabetes and Digestive and Kidney Diseases	P30DK078392

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production",

abstract = "Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 Tg /Cd300f -/- mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 Tg /Cd300f -/- mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f -/- mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 Tg /CD300f -/- were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.",

author = "Perri Rozenberg and Hadar Reichman and Israel Zab-Bar and Michal Itan and Metsada Pasmanik-Chor and Carine Bouffi and Udi Qimron and Ido Bachelet and Fulkerson, {Patricia C.} and Rothenberg, {Marc E.} and Ariel Munitz",

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doi = "10.1038/s41598-017-06397-4",

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AU - Rozenberg, Perri

AU - Reichman, Hadar

AU - Zab-Bar, Israel

AU - Itan, Michal

AU - Pasmanik-Chor, Metsada

AU - Bouffi, Carine

AU - Qimron, Udi

AU - Bachelet, Ido

AU - Fulkerson, Patricia C.

AU - Rothenberg, Marc E.

AU - Munitz, Ariel

PY - 2017/12/1

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N2 - Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 Tg /Cd300f -/- mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 Tg /Cd300f -/- mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f -/- mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 Tg /CD300f -/- were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.

AB - Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 Tg /Cd300f -/- mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 Tg /Cd300f -/- mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f -/- mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 Tg /CD300f -/- were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.

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CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production

Abstract

Bibliographical note

Funding

UN SDGs

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