CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

Jayanthi Jayawardena-Wolf; Kamel Benlagha; Ya Hui Chiu; Ramit Mehr; Albert Bendelac

doi:10.1016/S1074-7613(01)00240-0

CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

Jayanthi Jayawardena-Wolf, Kamel Benlagha, Ya Hui Chiu, Ramit Mehr, Albert Bendelac

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Princeton University

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d associates in the endoplasmic reticulum. Both pathways independently enhance antigen presentation to Vα14⁺ NKT cells, the main subset of CD1d-restricted T cells. These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1.

Original language	English
Pages (from-to)	897-908
Number of pages	12
Journal	Immunity
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(01)00240-0
State	Published - Dec 2001

Bibliographical note

Funding Information:
We thank S. Amigorena, C. Bonnerot, F. Castellino, C. Forestier, R. Germain, B. Jabri, L. Karlsson, I. Mellman, L. Teyton, H. Vincent-Schneider, G. Waters, and M. Weigert for helpful discussions, reagents, and technical advice, J. Goodhouse for help with confocal microscopy, and A. Beavis for assistance with flow cytometry. This work was supported by grants from the National Institutes of Health and the American Cancer Society, by a Leukemia and Lymphoma Society fellowship (to K.B), and by a Cancer Research Institute fellowship (to Y.-H.C).

Funding

We thank S. Amigorena, C. Bonnerot, F. Castellino, C. Forestier, R. Germain, B. Jabri, L. Karlsson, I. Mellman, L. Teyton, H. Vincent-Schneider, G. Waters, and M. Weigert for helpful discussions, reagents, and technical advice, J. Goodhouse for help with confocal microscopy, and A. Beavis for assistance with flow cytometry. This work was supported by grants from the National Institutes of Health and the American Cancer Society, by a Leukemia and Lymphoma Society fellowship (to K.B), and by a Cancer Research Institute fellowship (to Y.-H.C).

Funders	Funder number
National Institutes of Health
American Cancer Society
Cancer research institute
Leukemia and Lymphoma Society

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1074-7613(01)00240-0

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title = "CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain",

abstract = "Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d associates in the endoplasmic reticulum. Both pathways independently enhance antigen presentation to Vα14+ NKT cells, the main subset of CD1d-restricted T cells. These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1.",

author = "Jayanthi Jayawardena-Wolf and Kamel Benlagha and Chiu, {Ya Hui} and Ramit Mehr and Albert Bendelac",

note = "Funding Information: We thank S. Amigorena, C. Bonnerot, F. Castellino, C. Forestier, R. Germain, B. Jabri, L. Karlsson, I. Mellman, L. Teyton, H. Vincent-Schneider, G. Waters, and M. Weigert for helpful discussions, reagents, and technical advice, J. Goodhouse for help with confocal microscopy, and A. Beavis for assistance with flow cytometry. This work was supported by grants from the National Institutes of Health and the American Cancer Society, by a Leukemia and Lymphoma Society fellowship (to K.B), and by a Cancer Research Institute fellowship (to Y.-H.C).",

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AB - Endosomal trafficking is an essential component of the CD1 pathway of lipid antigen presentation to T cells. We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs intense recycling between the plasma membrane and the endosome, and by the invariant chain, with which CD1d associates in the endoplasmic reticulum. Both pathways independently enhance antigen presentation to Vα14+ NKT cells, the main subset of CD1d-restricted T cells. These results reveal the complexity of CD1d trafficking and suggest that the invariant chain was a component of ancestral antigen presentation pathways prior to the evolution of MHC and CD1.

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CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain

Abstract

Bibliographical note

Funding

UN SDGs

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