Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections

Yakov Shalom; Ilana Perelshtein; Nina Perkas; Aharon Gedanken; Ehud Banin

doi:10.1007/s12274-016-1310-8

Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections

Yakov Shalom
, Ilana Perelshtein
, Nina Perkas
, Aharon Gedanken
, Ehud Banin

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Catheter-associated urinary tract infections (CAUTIs) are among the most common bacterial infections associated with medical devices. In the current study, the synthesis, coating, antibiofilm properties, and biocompatibility of urinary catheters coated with Zn-doped CuO (Zn_0.12Cu_0.88O) nanoparticles (NPs) were examined. The doped NPs were synthesized and subsequently deposited on the catheter by the sonochemical method. The coated catheters displayed high antibiofilm activity and promising biocompatibility, as indicated by low in vitro cytotoxicity, negligible associated cytokine secretion, and absence of detectable irritation. The biocompatibility and ability of the Zn-doped CuO coating to inhibit biofilm formation were also evaluated in vivo using a rabbit model. Rabbits catheterized with uncoated catheters scored positive for CAUTI by day 4 of the experiment. In contrast, rabbits catheterized with Zn-doped CuO-coated catheters did not exhibit CAUTI until day 7 or remained completely uninfected for the whole duration of the 7-day experiment. Furthermore, the in vivo biocompatibility assays and examinations supported the biosafety of Zn-doped CuO-coated catheters. Taken together, these data highlight the potential of Zn-doped CuO nanocomposite as effective antibiofilm compound. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	520-533
Number of pages	14
Journal	Nano Research
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s12274-016-1310-8
State	Published - 1 Feb 2017

Bibliographical note

Publisher Copyright:
© 2017, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

Funding

This project was partially funded by a Kamin research grant from the Israeli Ministry of Economy to Ehud Banin. We also thank the Dyna and Fala Weinstock Foundation and the Douer Family Foundation for their support. We are grateful to Dr. Gal Yerushalmi and Yana Belnik for fruitful discussions and assistance in the preparation of the manuscript. We thank Yossi Lavie from Harlan for technical assistance and Dr. Abraham Nyska for histopathological analysis. We thank Katya Gotlib for technical assistance in the HRSEM.

Funders
Douer Family Foundation
Dyna and Fala Weinstock Foundation
Israeli Ministry of Economy to Ehud Banin

Keywords

antibiofilm
catheter
metal oxide
nanoparticle coating
urinary tract infection

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10.1007/s12274-016-1310-8

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title = "Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections",

abstract = "Catheter-associated urinary tract infections (CAUTIs) are among the most common bacterial infections associated with medical devices. In the current study, the synthesis, coating, antibiofilm properties, and biocompatibility of urinary catheters coated with Zn-doped CuO (Zn0.12Cu0.88O) nanoparticles (NPs) were examined. The doped NPs were synthesized and subsequently deposited on the catheter by the sonochemical method. The coated catheters displayed high antibiofilm activity and promising biocompatibility, as indicated by low in vitro cytotoxicity, negligible associated cytokine secretion, and absence of detectable irritation. The biocompatibility and ability of the Zn-doped CuO coating to inhibit biofilm formation were also evaluated in vivo using a rabbit model. Rabbits catheterized with uncoated catheters scored positive for CAUTI by day 4 of the experiment. In contrast, rabbits catheterized with Zn-doped CuO-coated catheters did not exhibit CAUTI until day 7 or remained completely uninfected for the whole duration of the 7-day experiment. Furthermore, the in vivo biocompatibility assays and examinations supported the biosafety of Zn-doped CuO-coated catheters. Taken together, these data highlight the potential of Zn-doped CuO nanocomposite as effective antibiofilm compound. [Figure not available: see fulltext.]",

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AU - Banin, Ehud

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N2 - Catheter-associated urinary tract infections (CAUTIs) are among the most common bacterial infections associated with medical devices. In the current study, the synthesis, coating, antibiofilm properties, and biocompatibility of urinary catheters coated with Zn-doped CuO (Zn0.12Cu0.88O) nanoparticles (NPs) were examined. The doped NPs were synthesized and subsequently deposited on the catheter by the sonochemical method. The coated catheters displayed high antibiofilm activity and promising biocompatibility, as indicated by low in vitro cytotoxicity, negligible associated cytokine secretion, and absence of detectable irritation. The biocompatibility and ability of the Zn-doped CuO coating to inhibit biofilm formation were also evaluated in vivo using a rabbit model. Rabbits catheterized with uncoated catheters scored positive for CAUTI by day 4 of the experiment. In contrast, rabbits catheterized with Zn-doped CuO-coated catheters did not exhibit CAUTI until day 7 or remained completely uninfected for the whole duration of the 7-day experiment. Furthermore, the in vivo biocompatibility assays and examinations supported the biosafety of Zn-doped CuO-coated catheters. Taken together, these data highlight the potential of Zn-doped CuO nanocomposite as effective antibiofilm compound. [Figure not available: see fulltext.]

AB - Catheter-associated urinary tract infections (CAUTIs) are among the most common bacterial infections associated with medical devices. In the current study, the synthesis, coating, antibiofilm properties, and biocompatibility of urinary catheters coated with Zn-doped CuO (Zn0.12Cu0.88O) nanoparticles (NPs) were examined. The doped NPs were synthesized and subsequently deposited on the catheter by the sonochemical method. The coated catheters displayed high antibiofilm activity and promising biocompatibility, as indicated by low in vitro cytotoxicity, negligible associated cytokine secretion, and absence of detectable irritation. The biocompatibility and ability of the Zn-doped CuO coating to inhibit biofilm formation were also evaluated in vivo using a rabbit model. Rabbits catheterized with uncoated catheters scored positive for CAUTI by day 4 of the experiment. In contrast, rabbits catheterized with Zn-doped CuO-coated catheters did not exhibit CAUTI until day 7 or remained completely uninfected for the whole duration of the 7-day experiment. Furthermore, the in vivo biocompatibility assays and examinations supported the biosafety of Zn-doped CuO-coated catheters. Taken together, these data highlight the potential of Zn-doped CuO nanocomposite as effective antibiofilm compound. [Figure not available: see fulltext.]

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Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections

Abstract

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Keywords

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