Catalyst and solvent-free, ultrasound promoted rapid protocol for the one-pot synthesis of α-aminophosphonates at room temperature

Bashir Dar; Amrinder Singh; Akshya Sahu; Praveen Patidar; Arup Chakraborty; Meena Sharma; Baldev Singh

doi:10.1016/j.tetlet.2012.07.123

Catalyst and solvent-free, ultrasound promoted rapid protocol for the one-pot synthesis of α-aminophosphonates at room temperature

Bashir Dar
, Amrinder Singh
, Akshya Sahu
, Praveen Patidar
, Arup Chakraborty
, Meena Sharma
, Baldev Singh

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

An ultrasound promoted easy, efficient, and environment friendly process has been devised for the synthesis of α-aminophosphonates within seconds through a one-pot three-component condensation of the aldehydes, amines, and triethylphosphite. The desired products were obtained in excellent yields and in high purity under solvent-free and catalyst-free conditions. Study with various aldehydes and amines reveals that ultrasound radiation plays a key role in the direct synthesis of α-aminophosphonates.

Original language	English
Pages (from-to)	5497-5502
Number of pages	6
Journal	Tetrahedron Letters
Volume	53
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2012.07.123
State	Published - 10 Oct 2012
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to the authorities of M/S Indian Institute of Integrated Medicine (IIIM), canal road, Jammu for providing necessary facilities and good environment to carry out the research work. We are also thankful to CSRI-DELHI for the financial support.

Funding

We are grateful to the authorities of M/S Indian Institute of Integrated Medicine (IIIM), canal road, Jammu for providing necessary facilities and good environment to carry out the research work. We are also thankful to CSRI-DELHI for the financial support.

Funders
CSRI-DELHI

Keywords

Catalyst free
Neat
One pot
Ultrasonication
α-Aminophosphonates

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10.1016/j.tetlet.2012.07.123

Cite this

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abstract = "An ultrasound promoted easy, efficient, and environment friendly process has been devised for the synthesis of α-aminophosphonates within seconds through a one-pot three-component condensation of the aldehydes, amines, and triethylphosphite. The desired products were obtained in excellent yields and in high purity under solvent-free and catalyst-free conditions. Study with various aldehydes and amines reveals that ultrasound radiation plays a key role in the direct synthesis of α-aminophosphonates.",

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AU - Singh, Amrinder

AU - Sahu, Akshya

AU - Patidar, Praveen

AU - Chakraborty, Arup

AU - Sharma, Meena

AU - Singh, Baldev

N1 - Funding Information: We are grateful to the authorities of M/S Indian Institute of Integrated Medicine (IIIM), canal road, Jammu for providing necessary facilities and good environment to carry out the research work. We are also thankful to CSRI-DELHI for the financial support.

PY - 2012/10/10

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KW - Catalyst free

KW - Neat

KW - One pot

KW - Ultrasonication

KW - α-Aminophosphonates

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Catalyst and solvent-free, ultrasound promoted rapid protocol for the one-pot synthesis of α-aminophosphonates at room temperature

Abstract

Bibliographical note

Funding

Keywords

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