Catalyst and solvent-free, ultrasound promoted rapid protocol for the one-pot synthesis of α-aminophosphonates at room temperature

Bashir Dar, Amrinder Singh, Akshya Sahu, Praveen Patidar, Arup Chakraborty, Meena Sharma, Baldev Singh

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

An ultrasound promoted easy, efficient, and environment friendly process has been devised for the synthesis of α-aminophosphonates within seconds through a one-pot three-component condensation of the aldehydes, amines, and triethylphosphite. The desired products were obtained in excellent yields and in high purity under solvent-free and catalyst-free conditions. Study with various aldehydes and amines reveals that ultrasound radiation plays a key role in the direct synthesis of α-aminophosphonates.

Original languageEnglish
Pages (from-to)5497-5502
Number of pages6
JournalTetrahedron Letters
Volume53
Issue number41
DOIs
StatePublished - 10 Oct 2012
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to the authorities of M/S Indian Institute of Integrated Medicine (IIIM), canal road, Jammu for providing necessary facilities and good environment to carry out the research work. We are also thankful to CSRI-DELHI for the financial support.

Keywords

  • Catalyst free
  • Neat
  • One pot
  • Ultrasonication
  • α-Aminophosphonates

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